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Erythroderma, an unusual manifestation of B cell lymphoma
Author(s) -
LEONG A. S. Y.,
COWLED P. A.,
ZALEWSKI P. D.,
BURRY J. N.,
MEREDITH D. J.,
FORBES I. J.
Publication year - 1978
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1978.tb01967.x
Subject(s) - lymphoma , pathology , medicine , scalp , histiocyte , erythroderma , lymph node , rash , lymphatic system , dermatology
SUMMARY A case is described in which the initial manifestation of a malignant lymphoma was an erythematous skin rash over the face, scalp and trunk. Immunological surface marker analysis showed the malignant cells to be of B lymphocyte origin with a homogeneous secretion of IgM‐k. Repeated skin and lymph node biopsies and finally post mortem documented the progression of the lymphoma from that of a mixed lymphocytic‐histiocytic type with a nodular pattern of growth to a diffuse histiocytic lymphoma with frequently bizarre cells. The theory of ecotaxis or homing of lymphocytes to the skin and other non‐lymphoid organs of the body is discussed in an attempt to explain the occurrence of cutaneous involvement as a primary manifestation of lymphcma.