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Immunoelectronmicroscopic examination of early lesions in histamine induced immune complex vasculitis in man
Author(s) -
WOLFF HELMUT H.,
MACIEJEWSKI W.,
SCHERER R.,
BRAUNFALCO O.
Publication year - 1978
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1978.tb01955.x
Subject(s) - basal lamina , vasculitis , immune complex , histamine , immune system , pathology , immunology , immunofluorescence , ultrastructure , chemistry , medicine , antibody , disease
SUMMARY In 4 cases of allergic vasculitis circulating immune complexes (IC) were demonstrated. Spontaneous and histamine induced vascular changes were studied by immunofluorescence microscopy. The early events in IC vasculitis were investigated at the ultrastructural level by immunoelectronmicroscopy using the peroxidase‐antiperoxidase multistep technique. Our findings support the concept that human IC vasculitis is triggered by the deposition of circulating IC in the walls of postcapillary venules between endothelial cells, pericytes and the layers of the basal lamina. Tissue destruction is only secondary due to local complement activation and the release of lysosomal enzymes from chemotactically attracted leukocytes.