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Skin reactions caused by vitamin K in patients with liver disease
Author(s) -
BULLEN A. W.,
MILLER J. P.,
CUNLIFFE W. J.,
LOSOWSKY M. S.
Publication year - 1978
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1978.tb01943.x
Subject(s) - medicine , disease , liver disease , dermatology , vitamin , gastroenterology
SUMMARY Vitamin K and its analogues are frequently used in treatment of the hypoprothrombinaemia found in disease of the liver, biliary tract and small intestine. Most cases of cutaneous toxicity to vitamin K have been described in the French literature, but only two cases from Britain. This paper reports six patients with chronic liver disease who developed cutaneous reactions around the site of injection of vitamin K, and the results of investigations to further understanding of the pathogenesis of the rash.