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Effects of topically potent glucocorticoids on human diploid fibroblasts in vitro
Author(s) -
KIRK DAVID,
MITTWOCH URSULA
Publication year - 1977
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1977.tb15430.x
Subject(s) - cancer genetics , library science , ploidy , in vitro , medicine , biology , genetics , computer science , gene , cancer
SUMMARY A wide range of concentrations of both cortisol and a topically more potent synthetic derivative, fluocinolone acetonide, was found not to inhibit the growth of cultured human skin fibroblasts; fluocinolone acetonide produced a slight increase in the growth rate. Both steroids had a transient stimulatory effect on fibroblasts, promoting an earlier entry into the period of DNA synthesis (S) which was also accompanied by a substantial increase in the length of S.