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Transcapillary escape rate of albumin and plasma volume in patients with varying degrees of psoriasis
Author(s) -
WORM ANNEMARIE,
ROSSING NIELS
Publication year - 1977
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1977.tb14252.x
Subject(s) - albumin , plasma volume , psoriasis , chemistry , medicine , serum albumin , endocrinology , volume (thermodynamics) , body surface area , lean body mass , blood plasma , body weight , immunology , physics , quantum mechanics
SUMMARY Plasma albumin, plasma volume and the transcapillary escape rate of albumin (TER alb ), i.e. the fraction ofthe intravascular mass of albumin that passes to the extravascular space per unit time, were determined using 125 I‐labelled albumin in 26 patients with varying degrees of psoriasis. For the patients as a group the plasma albumin concentration and the TER alb values were not significantly different from the control group. This contrasts with earlier findings in erythrodermic patients. The plasma volume was significantly reduced whether it was expressed in relation to body weight, height or surface area ( P <0.001). Thus the intravascular mass of albumin (IVM), determined as the product ofthe plasma volume and the plasma albimiin concentration, was also significantly reduced ( P <0.001). We found no correlation between the involved skin area and any ofthe above mentioned parameters. The possible mechanisms in the reduction of the plasma volume and the IVM are discussed. It is suggested that reduced IVM may refiect reduced total albumin mass due to lowered rates of albumin synthesis or increased rates of turnover.