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The effects of anti‐prostaglandin agents on epidermal proliferation induced by dermal inflammation
Author(s) -
FRANCIS A. J.,
MARKS R.
Publication year - 1977
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1977.tb14247.x
Subject(s) - epidermis (zoology) , hyperplasia , prostaglandin e , thymidine , inflammation , cell growth , prostaglandin , dna synthesis , endocrinology , chemistry , biology , medicine , pathology , in vitro , biochemistry , anatomy
SUMMARY Experimentally induced dermal inflammatory lesions cause epidermal hyperplasia and increased thymidine autoradiographic indices in the overlying epidermis. In the experiments described here anti‐prostaglandin agents (indomethacin, aspirin, prednisolone and polyphloretin phosphate) were given to guinea‐pigs with experimentally induced dermal granulomata in an effort to learn more about the dennal control of epidermal proliferation. Indomethacin caused a significant reduaion in the epidermal hyperplasia and labelling index in the epidermis overlying carageenan granulomata. Similar but less marked reductions in epidermal proliferation were seen with the other agents used. Some reduction, which proved not to be statistically significant, was also seen in the epidermal proliferation due to kaolin granulomata. Slight reduction in epidermal hyperplasia, but no effect on thymidine incorporation, was seen in proliferation induced by tape stripping.