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Drug‐induced changes in the plasma membrane of Microsporum canis
Author(s) -
PUCCINELLI V.,
INNOCENTI M.,
LASAGNI A.,
CAPUTO R.
Publication year - 1977
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1977.tb07155.x
Subject(s) - microsporum canis , drug , medicine , canis , microbiology and biotechnology , dermatology , pharmacology , biology , ecology , antifungal
SUMMARY Commercial solutions of clotrimazole, tolnaftate and tolcyclate were tested for 12 h in cultures of Microsporum canis . They induced modifications in particle distribution, a blebbing of particle‐free areas and the appearance of lamellar figures on the plasma membrane of fungus cells. The first two changes in the plasma membrane might be ascribed to a modification of the spectrin‐like meshwork, while the third could be the result of a crystalline organization of membrane lipids.