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Improvements in skin reactions to insulin, produced by a highly purified preparation
Author(s) -
DAGGETT PETER,
MUSTAFFA B.E.,
NABARRO J.D.N.
Publication year - 1977
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1977.tb07141.x
Subject(s) - insulin , skin reaction , medicine , dermatology , chemistry
SUMMARY A group of 14 patients with skin reactions to insulin have been treated with highly purified insulin over a period of 5–14 months while continuing to inject into the abnormal areas. Fat atrophy improved in all cases, coincident with a reduction in insulin requirement and insulin binding capacity. The response of patients with fat hypertrophy was less predictable, but there was an improvement in 3 out of 6 cases. Measurements of insulin binding capacity of the plasma suggested that fat atrophy and hypertrophy are immunologically distinct and some explanations for this are discussed. It is concluded that highly purified insulin benefits some patients with skin reactions to insulin.