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Anti‐inflammatory properties of a prostaglandin antagonist, a corticosteroid and indomethacin in experimental contact dermatitis
Author(s) -
LOWE NICHOLAS J.,
VIRGADAMO FRANK,
STOUGHTON RICHARD B.
Publication year - 1977
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1977.tb07140.x
Subject(s) - medicine , triamcinolone acetonide , oxazolone , erythema , contact dermatitis , antagonist , corticosteroid , pharmacology , prostaglandin , psoriasis , prostaglandin e2 , dermatology , allergy , immunology , receptor
SUMMARY The topical effects of N0164 (a phenyl phosphonate derivative which is a partially selective antagonist of prostaglandin E 2 ), indomethacin and triamcinolone acetonide have been shown to reduce the erythema and ear weight gain from inflammation induced by experimental contact allergic eczema. Oxazolone sensitized Swiss Webster mice were used, ear erythema and ear weights being used as a measure of the anti‐inflammatory response to the drugs. N0164 was also shown to have systemic anti‐inflammatory activity after intraperitoneal injection.