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The effect of intracutaneous injections of micronized crystalline suspensions of nandrolone phenylpropionate in the skin of female hairless hamsters
Author(s) -
CLARK M.A.,
PICTON W.
Publication year - 1977
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1977.tb06136.x
Subject(s) - hairless , dermis , nandrolone , thickening , epidermis (zoology) , hyperplasia , chemistry , medicine , endocrinology , anatomy , anabolism , biochemistry , polymer science
SUMMARY Single intracutaneous injections of micronized crystalline suspensions of nandrolone phenylpropionate * have been shown to induce local thickening of the epidermis of female hairless hamsters, accompanied by a marked increase in sebaccous gland volume over a period of 7 days. It is known that certain materials, when injected intracutaneously, may produce a diffuse inflammatory response in the dermis which in turn causes hyperplasia in the adjacent epidermis. The response observed in the present case, however, is clearly specific to nandrolone phenylpropionate, and cannot be attributed to an inflammatory response of the dermis to intracutaneously injected crystalline material.