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Acrokeratosis verruciformis (Hopf)—a clinical entity?
Author(s) -
PANJA RANJIT K.
Publication year - 1977
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1977.tb05209.x
Subject(s) - darier disease , dermatology , darier's disease , medicine , keratosis , dyskeratosis , disease , hyperkeratosis , malignant transformation , pathology
SUMMARY Contrary to the Unitarian concept of acrokeratosis verruciformis and Darier's disease, a comparative familial, clinical and histopathological analysis of six cases each of these two diseases has suggested that they are separate entities. Though clinically similar, acrokeratosis remained non‐dyskeratotic throughout life, whereas the acral lesions of Darier's disease showed, on careful scrutiny and follow‐up, various gradations of benign acantholytic dyskeratosis. Malignant transformation indicated that dyskeratosis in Hopf's disease would be very rare and of a different nature. The probability of a genetic linkage between the two genodermatoses is reviewed and discussed.