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Necropsy and ultrastructural findings in histiocytic medullary reticulosis
Author(s) -
PIÑOLAGUADÉ J.,
FERRANDO J.,
TOMÁS J.M.,
MIERAS C.,
PEYRÍ J.
Publication year - 1976
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1976.tb15533.x
Subject(s) - pathology , histiocyte , bone marrow , medullary cavity , spleen , lymph , infiltration (hvac) , lymphatic system , mesenteric lymph nodes , phagocytosis , ultrastructure , medicine , biology , immunology , physics , thermodynamics
SUMMARY In a case of histiocytic medullary reticulosis with protracted course and necrotic skin lesions, histological study revealed infiltration of the fat tissue by atypical rcticulohistiocytic cells, areas of asso‐ciated fat necrosis and vascular lesions. Autophagocytosis (phagocytosis of erythrocytes, erythroblasts, platelets, lymphoid cells, and nuclear debris) was found in biopsy specimens of the subcutaneous in‐filtrates, lymph nodes, and bone marrow, and in necropsy specimens of skin, iliac mesenteric lymph nodes, bone marrow, liver, spleen, and suprarenal glands. Electron microscopy of various viscera showed abnormal histiocytic cells containing multiple phagocytosed erythrocytes and other blood cells in different stages of destruction and digestion. Multi‐membranous bodies also were present. Defective lysosomal degradation of intracytoplasmatic ceroids in this condition is postulated.