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Histological and direct immunofluorescence study of cutaneous hyperreactivity in Behçet's disease
Author(s) -
HAIM S.,
SOBEL J.D.,
FRIEDMANBIRNBAUM R.,
LICHTIG C.
Publication year - 1976
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1976.tb07036.x
Subject(s) - behcet's disease , medicine , immunofluorescence , pathology , dermatology , direct fluorescent antibody , indirect immunofluorescence , behcet disease , disease , immunology , antibody
SUMMARY The mechanism of skin hyperreactivity (pathergy) in Behcet's disease is unknown. It has been suggested that the response is due to an Arthus‐like reaction. In 18 patients with active Behçet's disease, pathergy was induced and the skin biopsied after 24 h. The histological reaction was that of mild to intense round cell infiltration, perivascular in type. Direct immunofluorescence failed in all 18 patients to demonstrate the local presence of immunoglobulins and complement at the site of lesion. A marked increase in the number of mast cells was observed at the site of reaction and scattered throughout the dermis, the role of which is to be further investigated. The study failed to demonstrate a humoral mechanism in the production of the cutaneous hyperreactivity.