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The effect of long term tetracycline treatment for acne vulgaris on the occurrence of R factors in the intestinal flora of man
Author(s) -
VALTONEN M.V.,
VALTONEN V.V.,
SALO O.P.,
MÄKELÄ P.H.
Publication year - 1976
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1976.tb07019.x
Subject(s) - tetracycline , flora (microbiology) , acne , antimicrobial , antibiotics , microbiology and biotechnology , antibiotic resistance , clindamycin , medicine , biology , dermatology , bacteria , genetics
SUMMARY R factors are known to be the most important mechanism of antimicrobial resistance of intestinal flora. Short courses with therapeutic doses (1000 mg/day) of tetracycline select for strains containing transferable resistance factors to more than one antimicrobial agent. In this report we show that long term treatment with very low doses (100 mg/day) of tetracycline for acne vulgaris has an equally strong effect favouring establishment of resistant strains and R factors in the intestinal flora of patients.