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Immunological aspects of psoriasis
Author(s) -
GUILHOU J.J.,
MEYNADIER J.,
CLOT J.,
CHARMASSON E.,
DARDENNE M.,
BROCHIER J.
Publication year - 1976
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1976.tb07017.x
Subject(s) - psoriasis , medicine , dermatology
SUMMARY We have investigated lymphocyte subpopulations (six different markers) and T cell functions (mitogen responses and serum thymic factor determination) in twenty patients with psoriasis compared with thirty‐five healthy subjects. Normal results were found for B cell markers, but significantly lower numbers of T cells were assessed by E‐rosettes and anti HTLA serum. Mitogen responses were normal for PHA but depressed after Con A and PWM stimulation. Lastly, thymic factor levels were significantly higher in psoriasis than in normal subjects of the same age. These findings could be in favour of a T cell subpopulation defect involved in an auto‐immune pathogenesis of psoriasis.