Premium
Hypersensitivity to bacteria in eczema
Author(s) -
PARISH W.E.,
WELBOURN ESTHER,
CHAMPION R.H.
Publication year - 1976
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1976.tb07016.x
Subject(s) - antigen , teichoic acid , antibody , microbiology and biotechnology , chemistry , agglutination (biology) , staphylococcus aureus , lysis , protein a , biology , immunology , bacteria , genetics
SUMMARY The amounts of agglutinating antibody to staphylococcal and micrococcal phenol‐extracted (probably teichoic acids) and protein antigens, prepared from Baird Parker types SI, SIV and Ml, were no greater in eczematous than in control persons. Most antibody to phenol‐extracted antigens was IgM which frequently activated complement to lyse red cells which had adsorbed the bacterial antigen. IgG antibody against phenol‐extracted staphylococcal antigen ( Staph. aureus , Baird Parker type SI) was shown to be specific antibody combining by the F(ab)2 portion of the molecule. The phenol‐extracts did not contain staphylococcal Protein A that binds to the Fc portion of IgG. Furthermore, the presence of Protein A in the protein or total antigen extracts did not appear to modify the results of the tanned cell agglutination test. The occurrence of immediate or of 4 h, Arthus‐like skin test responses to staphylococcal or micrococcal antigens was unrelated to the agglutinin or complement‐lysis titre of the relevant antibody.