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Lysosomal hydrolases of the epidermis
Author(s) -
MIER P.D.,
HURK JOSÉ J.M.A.
Publication year - 1976
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1976.tb07014.x
Subject(s) - epidermis (zoology) , psoriasis , erythroderma , ichthyosis , biology , pathology , medicine , dermatology , endocrinology , anatomy
SUMMARY The activities of 14 acid hydrolases have been measured in normal and diseased human epidermis. Our findings were as follows: (i) Increased hydrolase activity was common in lesions; the clinically uninvolved skin of patients, however, invariably showed normal values. (2) The pattern of change was independent of the nature of the disease, the arylsulphatases and β‐glucosidase usually showing the greatest elevations. (3) The magnitude of the changes differed from disease to disease, being most marked in the lesions of psoriasis. (4) Ichthyosiform erythroderma was exceptional in showing elevated levels of the galactosidases and cathepsins B, and D. We suggest that (with the exception of ichthyosiform erythroderma) the abnormalities which we have observed may be related to the proliferative rate of the epidermis.