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Regression of a hamster melanoma with intralesional Corynebacterium granulosum
Author(s) -
PASLIN DAVID
Publication year - 1976
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1976.tb05163.x
Subject(s) - hamster , melanoma , dermatology , medicine , corynebacterium , microbiology and biotechnology , biology , cancer research , bacteria , genetics
SUMMARY The present study was undertaken to compare the antitumour effects of intralesionally administered Corynebacterium granulosum , Corynebacterium parvum , BCG and saline on a hamster melanoma. Forty‐eight golden hamsters were inoculated subcutaneously with Fortner's melanotic melanoma no. 1. Twenty‐four animals bore palpable tumours which were left in situ . The remaining twentyfour animals bore palpable tumours which were excised. No non‐excised group animal showed primary tumour regression. In the excised group, the tumours generally recurred at the excision site in the C . parvum , BCG and saline‐treated animals. By contrast, the incidence of recurrence was significantly reduced by intralesional injections of C . granulosum .