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Effects of short chain alcohols and hydrocarbon compounds on the adenylate cyclase of the skin
Author(s) -
YOSHIKAWA K.,
ADACHI K.,
HALPRIN K.M.,
LEVINE V.
Publication year - 1976
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1976.tb05159.x
Subject(s) - adenylate kinase , cyclase , incubation , ethanol , chemistry , acetone , phosphodiesterase , forskolin , incubation period , phosphodiesterase inhibitor , hydrocarbon , biochemistry , medicine , endocrinology , organic chemistry , enzyme , in vitro , biology
SUMMARY The cyclic AMP content of epidermal slices is increased by incubation with ethanol, the effect of which is dose‐dependent from 1 to 5% concentration in the incubation media. n‐Propanol and acetone are also effective at a concentration equimolar to 5% ethanol. Experimental results suggest that this effect of ethanol is due to activation of adenylate cyclase, rather than to the inactivation of cyclic AMP‐phosphodiesterase.