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A new model for human bioassay of topical corticosteroids
Author(s) -
REDDY B.S.N.,
SINGH GURMOHAN
Publication year - 1976
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1976.tb04369.x
Subject(s) - bioassay , histamine , human skin , medicine , dermatology , pharmacology , biology , genetics
SUMMARY The ability of topical corticosteroids to reduce the size of weals induced with histamine on human skin was used as a human bioassay model to assess their relative efficacy. Histamine was introduced by the pinprick method and various topical corticosteroids were assessed. It is a simple, easy and reliable procedure which can be used on both white and dark people. Even though it is a non‐clinical assay, it possesses close similarity to processes involved in the development of clinical dermatoses.