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The action of a urea—lactic acid ointment in ichthyosis
Author(s) -
BLAIR CICELY
Publication year - 1976
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1976.tb04363.x
Subject(s) - ichthyosis , urea , dermatology , action (physics) , lactic acid , medicine , chemistry , biochemistry , biology , bacteria , genetics , physics , quantum mechanics
SUMMARY The effect of urea—lactic acid ointment on the scales of ichthyotic skin was assessed using the ‘cell swelling’ technique of Christophers & Kligman. The thickness of the horny layer and of the scales was reduced both by the ointment and by the base. The formation of scales was shown to differ from that in psoriasis where the scale forms at the apex of a rete peg and is symmetrical whereas in ichthyosis the separation of the scale may be at an entirely different depth at one margin. There is an increase in the number of ‘T’ cells in X‐linked recessive ichthyosis.