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A comparison of histocompatibility antigens in dermatitis herpetiformis and adult coeliac disease
Author(s) -
SEAH P.P.,
FRY LIONEL,
KEARNEY J.W.,
CAMPBELL ELIZABETH,
MOWBRAY J.F.,
STEWART J.S.,
HOFFBRAND A.V.
Publication year - 1976
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1976.tb04361.x
Subject(s) - dermatitis herpetiformis , coeliac disease , histocompatibility , medicine , immunology , histocompatibility testing , antigen , disease , dermatology , human leukocyte antigen , pathology
SUMMARY The incidence of histocompatibility antigens HL‐A, 4a and 4b was studied in thirty‐eight patients with dermatitis herpetiformis (DH) and thirty‐six patients with adult coeliac disease (ACD). The 4b antigen was found in all the DH and ACD patients. HL‐A 8 was found in 89% of patients with ACD similar to the incidence reported in previous studies—and in 79% of patients with DH, a higher incidence than in previous studies which may be due to stricter criteria being used here to diagnose DH. There was no significant difference in the incidence of HL‐A 8 between those patients with DH whose small intestinal biopsies appeared macroscopically abnormal and those with a normal macroscopic appearance. These findings suggest that patients with DH form a single disease group and do not support the concept previously postulated that there are two groups of patients with DH, one with an increased incidence of HL‐A 8 antigen similar to that in ACD who have a gluten sensitive enteropathy (GSE), and another with a normal incidence of HL‐A 8 antigen and without enteropathy.