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Experimentally induced steroid atrophy in the domestic pig and man
Author(s) -
WINTER GEORGE D.,
BURTON J.L.
Publication year - 1976
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1976.tb02278.x
Subject(s) - fluocinolone acetonide , topical steroid , steroid , medicine , atrophy , forearm , dermatology , endocrinology , surgery , hormone
SUMMARY A histological method of ranking topical steroid preparations according to the degree of epidermal thinning they cause in pig skin has been shown to be applicable to human skin. A 0.05% ointment of the new compound, clobetasone butyrate (Molivate), has been shown to cause less thinning than either fluocinolone acetonide 0.025% (Synalar) or flurandrenolone 0.0125% (Haelan) when applied without the use of occlusive dressings for 3 weeks to the human forearm.