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The epidermis in thyroid disease *
Author(s) -
HOLT P.J.A.,
LAZARUS J.,
MARKS R.
Publication year - 1976
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1976.tb00861.x
Subject(s) - epidermis (zoology) , medicine , dermatology , thyroid disease , thyroid , anatomy
SUMMARY Epidermal dimensions, replication and anabolic activity have been studied in thirteen patients with thyrotoxicosis and seven patients with hypothyroidism. Epidermal thickness and rete pattern were signifieantly reduced in hypothyroidism. The rates of epidermal cell division and anabolic aetivity in the epidermis were estimated by measuring the rates of incorporation of tritiated precursor compounds and were found to be increased in thyrotoxicosis. The mean autoradiographic labelling indices after the intracutaneous injection of tritiated thymidine were 9.1% in thyrotoxic patients and 4.3% in the hypothyroid group. None of the changes observed could be correlated accurately with the degree of thyroid gland activity, but increased thyroid activity was reflected in the epidermal changes better than decreased thyroid activity.