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The sunburn cell in mouse skin: preliminary quantitative studies on its production
Author(s) -
WOODCOCK A.,
MAGNUS I.A.
Publication year - 1976
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1976.tb00854.x
Subject(s) - sunburn , photobiology , dermatology , library science , medicine , woodcock , biology , computer science , botany , ecology
SUMMARY Quantitative studies on sunburn cell (SBC) production in mouse epidermis are reported. Ultraviolet radiation (UVR), 260–300 nm, produced a dose related effect with respect to SBC formation. Maximal spectral reactivity was at wavelengths shorter than 300 nm. In 8‐methoxypsoralen (8‐MOP) photo‐sensitization, SBCs were also produced and this response is dose related with respect to long wave UVR dose. In fluorescein photosensitization, provoked by 487 nm light, SBCs were not produced. The response in 8‐MOP photosensitization and 254 nm UVR (given alone) differed in respect of time course, but it is considered that both may perhaps be initiated by a DNA lesion.