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Proprietary hydrocortisone creams
Author(s) -
BARRY B.W.,
WOODFORD R.
Publication year - 1976
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1976.tb00844.x
Subject(s) - blanching , hydrocortisone , hydrocortisone acetate , stratum corneum , significant difference , chemistry , medicine , dermatology , food science , pathology
SUMMARY Six proprietary hydrocortisone creams were evaluated for vasoconstrictor activities and bio‐availabilities using an occluded blanching test. Statistical analysis showed a significant difference between the formulations. Dioderm, containing 0.1% hydrocortisone, was significantly more active than the 1% hydrocortisone creams—Alphaderm, Calmurid HC, Efcortelan and Vioform‐Hydrocortisone. There was no significant difference between Dioderm and Dioderm C. Unlike creams containing more potent corticosteroids the hydrocortisone formulations apparently failed to produce steroid reservoirs in the stratum corneum as assessed by the blanching response.