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Dithranol (anthralin) versus triacetoxyanthracene
Author(s) -
RAAB WOLFGANG P.
Publication year - 1976
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1976.tb00826.x
Subject(s) - dithranol , chemistry , human skin , pharmacology , in vitro , dermatology , biochemistry , medicine , psoriasis , biology , genetics
SUMMARY In two in vitro models for evaluating antipsoriatic activity, dithranol (anthralin) and triacetoxyan‐thracene were compared. Both compounds exhibited an about equal effect on oxygen consumption of surviving human skin. Dithranol, however, exerted a stronger inhibiting effect on gIucose‐6‐phos‐phate dehydrogenase (G‐6‐PDH) activity of human skin homogenates.