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HL‐A antigens in patients with guttate psoriasis
Author(s) -
WILLIAMS R.C.,
McKENZIE A.W.,
ROGER J.H.,
JOYSEY V.C.
Publication year - 1976
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1976.tb00820.x
Subject(s) - psoriasis , medicine , antigen , human leukocyte antigen , immunology , dermatology , plaque psoriasis , population , environmental health
SUMMARY Tissue typing was performed on lymphocytes of sixty‐two patients with guttate psoriasis, in forty‐four of whom this was the first manifestation of the disease. In 84% of cases, the guttate psoriasis was preceded by a clinical infection. A highly significant excess of antigen W17 (HLA‐BW17) was found in patients when compared with a healthy population. In common with some other studies antigens HL‐A 13 (HLA‐B13), Wr5 (HLA‐BW15) and W21 (HLA‐BW21) were found in excess but these became non‐significant after correction for the number of antigens studied. 68% of patients who had guttate psoriasis de novo, subsequently developed persistent plaque psoriasis.