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Study of an inhibiting factor of epidermal proliferation in plucked skin and various tumours of mice
Author(s) -
GUIGON M.,
FRINDEL E.,
HEWITT J.,
TUBIANA M.
Publication year - 1976
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1976.tb00815.x
Subject(s) - art , medicine , library science , humanities , computer science
SUMMARY The aim of our research was to investigate, by autoradiographic meAods, the presence of an inhibitory factor (IF) in normal skin, in plucked skin and in five experimental skin tumours of the mouse, capable of inhibiting epidermal proliferation. The experimental model used was that of BuUough & Laurence (1960), i.e. a wound in the ear of a mouse. After tritiated thymidine administration the measurement of the labelling index confirmed the existence of an inhibitory substance in normal skin. The plucked skin had no inhibitory effect when it was taken 24 h after plucking, but after 4 days its effect had returned to normal. The skin tumours, whether epithelial or mesenchymal, showed the same inhibitory effect as normal skin whereas a non‐cutaneous tumour tested had no inhibitory effect.