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An improved method of assessing topical corticosteroid activity
Author(s) -
BARNES H.,
GAYLARDE P.M,
BROCK A.P,
SARKANY I.
Publication year - 1975
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1975.tb06520.x
Subject(s) - fluocinolone acetonide , corticosteroid , serial dilution , medicine , pharmacology , dermatology , chromatography , chemistry , endocrinology , pathology , alternative medicine
SUMMARY Topical application of ointment bases causes varying degrees of epidermal thickening in guinea‐pigs This is reproducible and can be accurately measured. Suppression of these changes was produced by addition of beta‐methasone 17‐valerate, fluocinolone acetonide, fluocinonide and hydrocortisone acetate. The inhibitory effect of these steroids was related to the type of corticosteroid, its concentration and the ointment base. The effect was still evident at extremely high dilutions of the steroids and could be measured at concentrations as low as 5 × 10 ‐5 % of fluocinonide in FAPG. This technique has the merits of being reproducible, sensitive and accurate. It should find a place among existing methods in assaying the efficacy of topical corticosteroids and in aiding the selection of bases most suitable for formulation of these preparations.