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A prospective study of the effects of weekly oral methotrexate on liver biopsy
Author(s) -
WARIN A.P.,
LANDELLS J.W.,
LEVENE G.M.,
BAKER H.
Publication year - 1975
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1975.tb06498.x
Subject(s) - medicine , reprint , psoriasis , methotrexate , dermatology , family medicine , general surgery , surgery , physics , astronomy
SUMMARY he results are reported of a prospective study of liver histological findings in twenty‐five patients with severe psoriasis subjected to liver biopsy before and at intervals after the onset of treatment with methotrexate by an intermittent dosage schedule. The pre‐methotrexate liver biopsy findings in forty‐one other severe psoriatics are also summarized. Of the twenty‐five treated patients, four showed a mild inflammatory cell infiltrate and two mild fibrosis before treatment. During treatment only one developed a grade 2 infiltrate and one other grade 2 fibrosis. None has developed cirrhosis. Where minor abnormalities developed, their fluctuating and reversible nature is demonstrated.