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Methotrexate pneumonitis in a psoriatic
Author(s) -
FROM E.
Publication year - 1975
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1975.tb06485.x
Subject(s) - methotrexate , medicine , dermatology , pneumonitis , psoriasis , lung
SUMMARY A life‐threatening respiratory disease, characterized by fever, cough, dyspnoea, cyanosis and widespread bilateral pulmonary infiltrates, developed in a 40‐year‐old patient receiving intermittent methotrexate therapy for psoriasis. Blood eosinophilia accompanied the illness. A prominent feature in the clinical picture was a discrepancy between auscultatory findings and the pronounced changes in the chest X‐ray. Systemic corticosteroids produced rapid improvement. It is suggested that the pulmonary syndrome represents a hypersensitivity reaction.