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Evaluation of coal tar fractions for use in psoriasiform diseases using the mouse tail test
Author(s) -
WRENCH ROSANNE,
BRITTEN ADAM Z.
Publication year - 1975
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1975.tb06478.x
Subject(s) - coal tar , tar (computing) , psoriasis , keratin , granular layer , anthracene , dermatology , chemistry , phenols , chromatography , biochemistry , medicine , organic chemistry , coal , pathology , computer science , cerebellum , programming language
SUMMARY Twelve phenolic fractions of creosote and anthracene oils derived from a high temperature tar were applied in an ointment base to mouse tail skin. After treatment with the higher boiling acids, formerly parakeratotic scale areas underwent granular layer induction and ‘basket‐weave’ keratin was produced. Changes in distribution of acid phosphatase and in horny layer fluorescence were consistent with the conversion to an orthokeratotic state. It is suggested that some of these phenols may be of value in the treatment of chronic psoriasis.