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Arterial thrombosis in scleroderma
Author(s) -
FUREY NANCY L.,
SCHMID F.R.,
KWAAN H.C.,
FRIEDERICI H.H.R.
Publication year - 1975
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1975.tb05119.x
Subject(s) - medicine , gangrene , thrombosis , thrombus , scleroderma (fungus) , amputation , pathological , vascular disease , infarction , cardiology , pathology , surgery , myocardial infarction , inoculation
SUMMARY Clinical and pathological observations are presented on five patients with scleroderma who developed Thrombosis of a major vessel. Three died following intestinal infarction or limb gangrene and two had digit or extremity amputations. Severe intimal thickening of major arteries with thrombus formation was noted but no significant abnormality was found in the clotting activity of the blood. Histochemical studies in three cases suggested a reduction of fibrinolytic activity at the site of thrombosis in the diseased vessels. These studies support the view that the vascular system is profoundly altered in scleroderma and may play an important role in some manifestations of the disease.