Premium
Studies on the energy metabolism in lichen planus
Author(s) -
HAMMAR HANS
Publication year - 1975
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1975.tb05117.x
Subject(s) - nad+ kinase , cofactor , enzyme , glycolysis , nicotinamide adenine dinucleotide , nicotinamide , mitochondrion , pentose phosphate pathway , metabolism , biochemistry , chemistry , biology
SUMMARY Various epidermal enzymes and cofactors were measured in patients with lichen planus and in healthy controls with the aid of Lowry's microtechniques, including enzymatic cycling. The steady‐state levels of the nicotinamide adenine dinucleotides NAD* and NADP were decreased and this was evident even in areas still free from lesions. The oxidized and reduced portions of NAD were altered indicating changed equilibria of NAD dependent dehydrogenases. Reduced NADP was more tightly controlled at the normal level which is regarded as evidence of an unaltered biosynthetic potential in this disease. In conjunction with earlier data the results indicate a preserved glycolytic and pentose shunt activity while the mitochondria display signs of dysfunction.