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Treatment of solar keratoses of the extremities with retinoic acid and 5‐fluorouracil
Author(s) -
ROBINSON TERRANCE A.,
KLIGMAN ALBERT M.
Publication year - 1975
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1975.tb03153.x
Subject(s) - actinic keratoses , medicine , dermatology , tretinoin , fluorouracil , keratosis , retinoic acid , cancer , basal cell , chemistry , biochemistry , gene
SUMMARY In contrast to solar keratoses of the face, twice daily application of 5% s‐fluorouracil cream was found to be incapable of destroying such lesions situated on the forearms and hands. Twice daily application of 0.1% retinoic acid was also ineffective. Combined use of these agents eradicated keratoses in all twenty subjects with numerous keratoses of the forearms; in only two was the treatment ineffective for keratoses of the hands.