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Mucocutaneous leishmaniasis in guinea‐pigs inoculated intravenously with Leishmania enriettii
Author(s) -
KANAN M.W.
Publication year - 1975
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1975.tb03147.x
Subject(s) - mucous membrane of nose , leishmaniasis , granuloma , mucocutaneous zone , giant cell , pathology , biology , inoculation , histology , scrotum , leishmania , guinea pig , medicine , anatomy , parasite hosting , disease , world wide web , computer science , endocrinology
SUMMARY Seven guinea‐pigs were inoculated intravenously with a rich suspension of Leishmania enricitii . During the sixth to the seventh week from inoculation, all of them developed lesions within the anrcrior nasal mucosa and in the vulva or scrotum. In one animal nodules occurred in the forepaws during the tenth week. The histology of the latter showed an cpithclioid granuloma with multinucleate giant cells, while in all the others macrophages and monocytes highly parasitized with leishmania bodies, formed the main elements in the granulomatous infiltrate. Lesions seem to develop in the cool, non‐hairy areas of the integument and those areas of the nasal mucosa which are constantly bombarded by the inhaled cool air stream. The anterior nasal mucosa, with its leaking venular network, its cool temperature, relative stasis and hypoxia probably provides the optimum micro‐environment for the localization, survival and multiplication of tho leishmanial protozoon.