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Prostaglandins and cyclic AMP in epidermis
Author(s) -
ADACHI KENJI,
YOSHIKAWA KUNIHIKO,
HALPRIN KENNETH M.,
LEVINE VICTOR
Publication year - 1975
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1975.tb03097.x
Subject(s) - epidermis (zoology) , chemistry , medicine , endocrinology , biophysics , biology , anatomy
SUMMARY Prostaglandins E 1 and E 2 stimulate cyclic AMP accumulation in pig epidermis and in human epidermis from patients with psoriasis. Prostaglandins A 1 , A 2 and F 2α are relatively ineffective. The fact that this stimulation is not inhibited by a β‐blocker (propranolol) and that the stimulation by prostaglandin E 2 and adrenaline is additive indicates that each drug acts independently on the epidermal adenyl cyclase system. In other words, prostaglandins E 1 and E 2 act on a site other than the β‐receptor of adenyl cyclase in epidermis. The stimulation by prostaglandins E 1 and E 2 is not additive; hence they probably act on the same site. Concentrations of prostaglandin E above 3 × 10 −7 M are effective in causing stimulation. This concentration may be within the physiological range and the contribution of endogenous prostaglandin levels in the control of intracellular cyclic AMP levels cannot be disregarded.