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Comparative bio‐availability and activity of properietary topical corticosteroid preparations: vasoconstrictor assays on thirty‐one ointments
Author(s) -
BARRY B.W.,
WOODFORD R.
Publication year - 1975
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1975.tb02250.x
Subject(s) - blanching , medicine , corticosteroid , antimicrobial , vasoconstriction , pharmacology , dermatology , anesthesia , chemistry , surgery , food science , organic chemistry
SUMMARY Thirty‐one proprietary corticosteroid ointments were evaluated for vasoconstriction using an occluded blanching test. The results were expressed as three parameters: (I) area under the blanching curve, (2) summed % total possible score, and (3) square root transformation of sum of scores divided by number of volunteers. Experiments were performed to (a) compare the bio‐availability and activity of the ointments, (b) determine the effect of antimicrobial additives, and (c) assess the retention of steroids in the skin. Scores for the additive‐containing and ‘plain’ preparations were within 90% except for Locorten‐Vioform/Locorten (58%). A steroid reservoir in the skin was demonstrated lasting for 8–14 days. Selected preparations were‐re‐tested by a non‐occluded method. The results for the ointments were compared with those previously obtained using the corresponding creams.