Premium
Nickel hypersensitivity
Author(s) -
HUTCHINSON F.,
MACLEOD T.M.,
RAFFLE E.J.
Publication year - 1975
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1975.tb02249.x
Subject(s) - nickel , hapten , conjugate , chemistry , lymphocyte , immunology , delayed hypersensitivity , transformation (genetics) , medicine , antigen , biochemistry , organic chemistry , mathematical analysis , mathematics , gene
SUMMARY The nature of a protein hapten conjugate which could effect lymphocyte transformation in nickel hypersensitivity was investigated by subjecting the culture media employed to radiochromatographic analysis. Autoradiographic studies with 63 Ni demonstrate direct binding of nickel salts to the lymphocyte cell surface. This occurs with a proportion of lymphocytes both from nickel sensitive and from control subjects and so binding is not of itself the stimulus for transformation.