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Dithranol (anthralin) in psoriasis
Author(s) -
LIDÉN S.,
LËSSON G. MICHA
Publication year - 1974
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1974.tb13085.x
Subject(s) - dithranol , psoriasis , dna , dermatology , thymidine , dna synthesis , parakeratosis , pathology , biopsy , in vitro , medicine , chemistry , biochemistry
SUMMARY Biopsies from affected skin of sixty‐two patients with stable psoriasis were investigated by in vitro labelling with tritiated thymidine and by routine histological techniques. In the same patient there were considerable variations in the number of DNA‐synthesizing cells in biopsies taken from different but similarly located lesions of the same macroscopic appearance, whereas variations in the number of DNA‐synthesizing cells in biopsies taken from the same lesions were less pronounced. With due regard given to this finding, it is shown that treatment with dithranol for 1 and 2 weeks significantly reduces the number of DNA‐synthesizing cells. There was an inverse relationship comparing the development of the granular layer with the number of DNA‐synthesizing cells and parakeratosis. The variations in the number of DNA‐synthesizing cells in different lesions in the same patient may also have implications for paired comparisons of topical treatment efficiency.