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Incorporation of D‐amphetamine into pigmented guinea‐pig hair
Author(s) -
HARRISON W. H.,
GRAY R. M.,
SOLOMON L. M.
Publication year - 1974
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1974.tb13079.x
Subject(s) - amphetamine , melanosome , melanin , guinea pig , hair shaft , chemistry , black hair , pharmacology , biology , endocrinology , dopamine , hair follicle , biochemistry , genetics
Summary Incorporation of D‐amphetamine into the hair of a black‐pigmented guinea‐pig was measured by a 14 C‐tracer method. D‐Amphetamine administered intraperitoneally was found to be incorporated into the hair, and part of the radioactivity was found in isolated melanin. The findings are in conformity with the concept that D‐amphetamine gains access to melanocytes through the arteriovenous or lymphatic circulation, enters melanosomes, interacts with the melanosomal protein and melanin, and resides ultimately in the pigment granules in the hair fibre. The findings suggest a pathway which may influence the biological activity of this and related drugs.