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A case of purpura hyperglobulinaemica of Waldenström studied by skin immunofluorescence
Author(s) -
PERKS W. H.,
GREEN F.,
GLEESON M. H.
Publication year - 1974
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1974.tb12945.x
Subject(s) - immunofluorescence , purpura (gastropod) , direct fluorescent antibody , medicine , pathogenesis , antibody , pathology , immunology , dermatology , biology , ecology
SUMMARY A case of purpura hyperglobulinaemica of Waldenström is reported. Immunofluorescence of skin and subcutaneous tissue using monospecific fluorescein‐tagged anti‐human IgA, IgG, IgM and complement showed deposition of IgA in the walls of intradermal vessel in affected skin. It is suggested that these findings help in the elucidation of the pathogenesis of the purpura.