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The effect on plasma corticosteroid levels of the short term topical application of clobetasol propionate
Author(s) -
WALKER STUART R.,
WILSON LYN,
FRY LIONEL,
JAMES V. H. T.
Publication year - 1974
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1974.tb12904.x
Subject(s) - clobetasol propionate , corticosteroid , medicine , term (time) , dermatology , plasma levels , physics , quantum mechanics
SUMMARY Thirty‐four patients with skin diseases which necessitated treatment with potent topical steroids at a hospital clinic were studied. All the patients received clobetasol propionate ointment (Dermovate) for a period of 2 weeks and sixteen of the patients continued with their treatment for 4 weeks, during which time their plasma corticosteroid levels were measured. Thirty patients had normal levels throughout the whole period of study (≥ 6 μg/100 ml) and five patients showed a depressed level at some stage during the investigation. Of six patients who were using a large amount of clobetasol ointment (more than 100 g/week) and who had a significant proportion of their body affected by disease (20‐80%), two had lowered plasma corticosteroid levels and in four there was no evidence of adrenal suppression.