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Percutaneous absorption and the surface area of occluded skin
Author(s) -
HARRIS DAVID R.,
PAPA CHRISTOPHER M.,
STANTON RAYMOND
Publication year - 1974
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1974.tb06713.x
Subject(s) - stratum corneum , human skin , chemistry , biophysics , biomedical engineering , anatomy , pathology , medicine , biology , genetics
SUMMARY Scanning electron microscopy of samples of human skin occluded for 72 h, revealed that the hydrated stratum corneum not only swells, but develops multiple folds. Surface area estimations of such stratum corneum, utilizing stereo pairs of the photomicrographs, indicated a 37% increase over the normal, non‐occluded horny layer values. It is speculated that the increase in absorptive area contributes to the increased skin permeability following occlusion.