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Leukocyte migration inhibition in progressive systemic sclerosis
Author(s) -
HUGHES P.,
HOLT SHIRLEY,
ROWELL N.R.
Publication year - 1974
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1974.tb06709.x
Subject(s) - progressive systemic sclerosis , antigen , immunology , myelin , heterologous , homologous chromosome , multiple sclerosis , cellular immunity , medicine , biology , pathology , central nervous system , endocrinology , disease , biochemistry , gene
SUMMARY The leukocyte migration test was used to examine patients with progressive systemic sclerosis for evidence of cell‐mediated immunity to a wide range of autologous, homologous and heterologous antigens. Ten patients with progressive systemic sclerosis and seventeen normal controls were tested for sensitivity to autologous lymphocytes, microsomal and mitochondrial fractions of human cadaver liver, human myelin basic protein and porcine thyroglobulin. Migration indices in the control group showed a uniform response with, in general, only minimal reactivity for each of the antigens tested. By contrast, the patients with progressive systemic sclerosis showed a significantly greater degree of migration‐inhibition using autologous lymphocytes, the liver microsomes and mitochondria, and the myelin basic protein. Leukocyte migration in the presence of porcine thyroglobulin did not differ, however, from that in the normal controls. The findings indicate that there is in progressive systemic sclerosis, widespread cell‐mediated hypersensitivity, much of which is directed against both autologous and homologous antigens.