Premium
Actinic reticuloid: an immunological investigation providing evidence of basement membrane damage
Author(s) -
MENTER M. A.,
McKERRON R. A.,
AMOS H. E.
Publication year - 1974
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1974.tb06445.x
Subject(s) - basement membrane , fibrin , pathogenesis , pathology , immunofluorescence , medicine , chemistry , dermatology , immunology , antibody
SUMMARY Twelve cases of actinic reticuloid have been investigated using immunological procedures. It was shown that the patients were fully competent immunologically and no evidence was found to support a photo‐allergic mechanism in the pathogenesis of the disease. The importance of the basement membrane zone as a site of tissue damage was observed by the finding of a localized band of fibrin deposition in this site using immunofluorescence techniques. Further, it was shown that, by irradiating uninvolved skin at 360 nm, an infiltrate simulating a lymphoma was produced by 24 h. It was concluded that the fibrin deposition was secondary to the infiltrate.