Premium
Reduced activation of epidermal phosphorylase in the lesions of psoriasis
Author(s) -
MIER P. D.,
JOSE J.M.A.,
HURK VAN
Publication year - 1974
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1974.tb06408.x
Subject(s) - psoriasis , epidermis (zoology) , lesion , glycogen phosphorylase , enzyme , dermatology , medicine , chemistry , endocrinology , pathology , biochemistry , anatomy
SUMMARY The percentage activation of the enzyme phosphorylase in extracts prepared from the epidermis of psoriatic lesions was found to be significantly lower than normal. This observation lends strong support to the concept of a reduced level of cyclic AMP in the lesion of this disease.