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Topical indomethadn and sunburn
Author(s) -
SNYDER DIANE SEKURA,
EAGLSTEIN WILLIAM H.
Publication year - 1974
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1974.tb06366.x
Subject(s) - sunburn , erythema , medicine , dermatology , aspirin , prostaglandin e2 , prostaglandin , corticosteroid , surgery
SUMMARY This study has demonstrated that a single application of a 2–5% solution of indomethacin will decrease the redness, warmth, and tenderness of sunburned skin for 24 h or longer. For this purpose indomethacin is much more effective than a highly active corticosteroid cream. Prostaglandins appear to be important mediators of ultraviolet erythema (Greaves, Sondergaard& McDonald‐Gibson, 1971; Mathur & Gandhi, 1972). We reported that prostaglandin inhibitors, indomethacin and aspirin, injected intradermally, delay and decrease ultraviolet erythema (Snyder & Eaglstein, 1973). In this study we have evaluated the effects of topically applied indomethacin and a corticosteroid on sunburn induced by a sunlamp or by natural sunlight.