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Wound healing in the oral mucosa of the acutely insulin deprived rat
Author(s) -
JOLLY MARK,
COOKE NIGEL T.
Publication year - 1974
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1974.tb06359.x
Subject(s) - wound healing , epithelium , glycogen , insulin , streptozotocin , oral mucosa , medicine , diabetes mellitus , endocrinology , pathology , surgery
SUMMARY Standard wounds were produced on the palates of streptozotocin‐induced ‘diabetic’ and normal rats. Healing, as estimated by the extent of epithelial migration after 24 h, was found to be identical in the two groups. The accumulation of glycogen and PAS positive, diastase‐resistant material in the epithelium at the wound margins was far greater in the diabetic animals than in the controls. Indirect evidence is presented suggesting that the passage of glucose into epithelial cells is independent of insulin control. The investigation was planned to assess two aspects of wound healing in the mouths of ‘diabetic’ rats compared with normal controls: (1) The ability of epithelium to migrate across a wound. (2) The accumulation of glycogen in the epithelium at the wound margins.